Head of IRCCS Istituto delle Scienze Neurologiche di Bologna
Head of UOC Clinica Neurologica – Rete Neurologica Metropolitana (NeuroMet), IRCCS Istituto delle Scienze Neurologiche di Bologna
Full Professor of Neurology at Alma Mater Studiorum – University of Bologna

PhD Student, Department of Biomedical and Neuromotor Sciences
Neurologist, UOC Clinica Neurologica – Rete Neurologica Metropolitana (NeuroMet), IRCCS Istituto delle Scienze Neurologiche di Bologna

Associate Professor of Medical Genetics at the University of Pavia, Italy
Research Interest
The recently set up Giorgio Lab deals with the genetics of nuerodegenerative and neurodevelopmental disorders, with a particular focus on a rare form of leukoencephalopathy, the adult-onset autosomal dominant leukodystrophy (ADLD). The lab is focuesd on the identification of gnetics diseases associated with non-canonical mutations and on the development of therapuetic strategies for rare genetic diseases by RNA therapuetics and drug-repositioning apporaches

Full Professor of Human Anatomy
Head of the Cellular Signalling Laboratory
Scientific Referent of the Collection of Anatomical Waxes “L.Cattaneo”
Center for Experimental Molecular Surgical and Clinical Anatomy
Department of Biomedical and Neuromotor Sciences – School of Medicine and Surgery
Alma Mater Studiorum – University of Bologna
Research Interest
The Cellular Singalling Laboratory has been focused for several years on studying the molecular mechanisms of rare diseases such as adult-onset Autosomal Dominant Leukodystrophy (ADLD), glioblastoma and other forms of cancers. Recently, the lab demonstrated that cellular alterations in ADLD are primarily related to astrocytes, suggesting that such cellular distress could negatively impact myelin production and maintenance by oligodendrocytes. The lab’s goal involves molecular mechanisms characterization associated with demyelination with the use of innovative patient-specific cellular and organoid models for drug testing and establishing new treatments for ADLD.

Associate Professor of Human Anatomy at the University of Bologna, Italy
Research Interest
Prof. Ramazzotti has been conducting her research at the Cellular Signaling Laboratory with a focus on studying signal transduction networks in different neurological disorders including Autosomal Dominant Leukodystrophy (ADLD) and on the investigation of the interactions between different cell types in the microenvironment of the nervous system. She has also been studying for several years demyelination in ADLD for unraveling the disease pathomechanisms and establishing therapy. Other aspects of her research include phosphoinositide-related signaling pathways in myogenic and osteogenic differentiation, focusing on the identification of new effectors located both in the nuclear and/or in the cytosolic compartment. Additionally, Prof. Ramazzotti studied the regulation of signaling pathways in adipose-derived stem cells differentiation towards different lineages. 

Medical Director of Neurology at the II Neurological Clinic, Neurosciences Department, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino
Research Interest
Since many years she is in charge of the Demyelinating Diseases and white matter Clinic at the II Neurological Clinic, directed by Prof. Lopiano, with a focus on rare genetic diseases. In particular, she takes care of the “SM mimics” Clinic, which treats patients with undefined diagnosis of leukoencephalopathies.

PhD Candidate at the Cellular Signaling Laboratory of the Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy
Research Interest
Foteini is a PhD candidate at the Cellular Signaling Laboratory studying the underlying pathomechanisms of Autosomal Dominant Leukodystrophy (ADLD). Her research is focused on investigating the morpho-functional and demyelination mechanisms associated with ADLD on patient-specific 3D models for drug testing and therapy establishment.